abstract：:Aberrant brain functional connectivity has been considered as the important mechanism underlying minimal hepatic encephalopathy (MHE); however, little is known about the change in interhemispheric connection in MHE patients. Twenty patients with HBV-related cirrhosis and MHE and 15 healthy controls were included in th...

journal_title：Metabolic brain disease

authors： Chen HJ,Wang Y,Yang M,Zhu XQ,Teng GJ

更新日期：2014-09-01 00:00:00

abstract：:Hepatic encephalopathy (HE) is a neuropsychiatric syndrome which develops in patients with severe liver diseases and/or portal-systemic shunting. Minimal HE, the earliest manifestation of HE, has drawn increasing attention in the last decade. Minimal HE is associated with a series of brain functional changes, such as ...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wu S,Ren J,Lu GM

更新日期：2014-09-01 00:00:00

abstract：:The aim of the present work was to investigate the role of ondansetron on the high fat diet (HFD) induced obese mice for behavioral and biochemical alterations using chronic unpredictable mild stress (CUMS) model of depression. Animals were fed with high fat diet for 14 weeks and subjected to different stress procedur...

journal_title：Metabolic brain disease

authors： Kurhe Y,Radhakrishnan M,Gupta D

更新日期：2014-09-01 00:00:00

abstract：:Iron is an important micronutrient for neuronal function and survival. It plays an essential role in DNA and protein synthesis, neurotransmission and electron transport chain due to its dual redox states. On the contrary, iron also catalyses the production of free radicals and hence, causes oxidative stress. Therefore...

journal_title：Metabolic brain disease

authors： Minhas G,Modgil S,Anand A

更新日期：2014-09-01 00:00:00

abstract：:Alcohol dependence (AD) has a large heritable component. Genetic variation in genes involved in the absorption and elimination of ethanol have been associated with AD. However, some of these polymorphisms are not present in an African population. Previous studies have reported that a type of AD which is characterized ...

journal_title：Metabolic brain disease

authors： Crawford A,Dalvie S,Lewis S,King A,Liberzon I,Fein G,Koenen K,Ramesar R,Stein DJ

更新日期：2014-06-01 00:00:00

abstract：:While alcohol-induced psychotic disorder (AIPD) is well recognised, relatively little is known about the condition. We undertook a review of the literature to identify studies on the epidemiology, clinical manifestations, underlying neurobiology and treatment of AIPD. Few prospective studies have been conducted on AIP...

journal_title：Metabolic brain disease

authors： Jordaan GP,Emsley R

更新日期：2014-06-01 00:00:00

abstract：:While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children includi...

journal_title：Metabolic brain disease

authors： Bumoko GM,Sombo MT,Okitundu LD,Mumba DN,Kazadi KT,Tamfum-Muyembe JJ,Lasarev MR,Boivin MJ,Banea JP,Tshala-Katumbay DD

更新日期：2014-06-01 00:00:00

abstract：:There is substantial clinical and experimental evidence that ammonia is a major factor in the pathogenesis of hepatic encephalopathy. In the article is demonstrated that in hepatocellular dysfunction, ammonia detoxification to glutamine (GLN) in skeletal muscle, brain, and likely the lungs, is activated. In addition t...

journal_title：Metabolic brain disease

authors： Holecek M

更新日期：2014-03-01 00:00:00

abstract：:Pipecolic acid (PA) levels are increased in severe metabolic disorders of the central nervous system such as Zellweger syndrome, infantile Refsum disease, neonatal adrenoleukodystrophy and hyperlysinemia. The affected individuals present progressive neurological dysfunction, hypotonia and growth retardation. The mecha...

journal_title：Metabolic brain disease

authors： Dalazen GR,Terra M,Jacques CE,Coelho JG,Freitas R,Mazzola PN,Dutra-Filho CS

更新日期：2014-03-01 00:00:00

abstract：:Hyperphenylalaninemia (HPA) leads to increased oxidative stress in patients with phenylketonuria (PKU) and in animal models of PKU. Early diagnosis and immediate adherence to a phenylalanine-restricted diet prevents HPA and, consequently, severe brain damage. However, treated adolescent and adult PKU patients have dif...

journal_title：Metabolic brain disease

authors： Mazzola PN,Karikas GA,Schulpis KH,Dutra-Filho CS

更新日期：2013-12-01 00:00:00

abstract：:To investigate the pattern of brain volume changes in patients with end-stage renal disease (ESRD) using voxel-based morphometry (VBM) and correlation with clinical and neuropsychological (NP) tests. Fifty seven ESRD patients with no anatomical abnormalities in conventional magnetic resonance imaging [24 patients with...

journal_title：Metabolic brain disease

authors： Zhang LJ,Wen J,Ni L,Zhong J,Liang X,Zheng G,Lu GM

更新日期：2013-12-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disease whose hallmark pathological features include a selective loss of dopaminergic neurons in the midbrain. Ciclooxygenase-2 activity induction and oxidative stress have been implicated in the aetiology of Parkinson's disease and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydro...

journal_title：Metabolic brain disease

authors： Ortiz GG,Pacheco-Moisés FP,Gómez-Rodríguez VM,González-Renovato ED,Torres-Sánchez ED,Ramírez-Anguiano AC

更新日期：2013-12-01 00:00:00

abstract：:Tissue methylmalonic acid (MMA) accumulation is the biochemical hallmark of methylmalonic acidemia. Clinically, the disease is characterized by progressive neurological deterioration and renal failure, whose pathophysiology is still undefined. In the present study we investigated the effect of acute MMA administration...

journal_title：Metabolic brain disease

authors： Affonso AC,Machado DG,Malgarin F,Fraga DB,Ghedim F,Zugno A,Streck EL,Schuck PF,Ferreira GC

更新日期：2013-09-01 00:00:00

abstract：:Schizophrenia is one of the most disabling mental disorders that affects up to 1 % of the population worldwide. Although the causes of this disorder remain unknown, it has been extensively characterized by a broad range of emotional, ideational and cognitive impairments. Studies indicate that schizophrenia affects neu...

journal_title：Metabolic brain disease

authors： Zugno AI,Julião RF,Budni J,Volpato AM,Fraga DB,Pacheco FD,Deroza PF,Luca RD,de Oliveira MB,Heylmann AS,Quevedo J

更新日期：2013-09-01 00:00:00

abstract：:Susceptibility to Wilson's disease (WD) and its clinical manifestations are thought to be affected by genetic factors, including polymorphisms. The role of brain-derived neurotrophic factor (BDNF) in the pathogenesis of neurodegenerative diseases is now widely discussed. The aim of the present study was to evaluate th...

journal_title：Metabolic brain disease

authors： Mirowska-Guzel D,Litwin T,Gromadzka G,Czlonkowski A,Czlonkowska A

更新日期：2013-09-01 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (ICH) represents a partially-understood cerebrovascular disease of high incidence, morbidity and mortality. We, herein, report the findings of our study concerning the role of two important adenosinetriphosphatases (ATPases) in a porcine model of spontaneous ICH that we have recent...

journal_title：Metabolic brain disease

authors： Bimpis A,Papalois A,Tsakiris S,Kalafatakis K,Zarros A,Gkanti V,Skandali N,Al-Humadi H,Kouzelis C,Liapi C

更新日期：2013-09-01 00:00:00

abstract：:Hepatic encephalopathy is a common complication of hepatic cirrhosis. The clinical diagnosis is based on two concurrent types of symptoms: impaired mental status and impaired neuromotor function. Impaired mental status is characterized by deterioration in mental status with psychomotor dysfunction, impaired memory, an...

journal_title：Metabolic brain disease

authors： Malaguarnera M

更新日期：2013-06-01 00:00:00

abstract：:Glutaric aciduria type I (GA-I) is an inborn error of lysine and tryptophan metabolism. Clinical manifestations of GA-I include dystonic or dyskinetic cerebral palsy, but when the symptoms occur, treatment is not effective. In Taiwan, newborn screening for GA-I started in 2001; we wish to evaluate the outcomes of pati...

journal_title：Metabolic brain disease

authors： Lee CS,Chien YH,Peng SF,Cheng PW,Chang LM,Huang AC,Hwu WL,Lee NC

更新日期：2013-03-01 00:00:00

abstract：:Mitochondrial glutathione (mGSH) is a critical factor in the cell defense against oxidative and nitrosative stress (ONS), and ONS is a key pathogenic event in hepatic encephalopathy (HE). Acute HE in the thioacetamide (TAA) model caused a 54 % decrease of mGSH content in the rat prefrontal cortex (pfc), but not in the...

journal_title：Metabolic brain disease

authors： Ruszkiewicz J,Fręśko I,Hilgier W,Albrecht J

更新日期：2013-03-01 00:00:00

abstract：:Over the past 35 years, the outlook for a patient presenting with acute liver failure (ALF) has changed beyond all recognition. A patient presenting in 1984 had an 80 % likelihood of succumbing to intracranial hypertension. Today due to dramatic improvements in intensive care in dedicated liver transplant units, this ...

journal_title：Metabolic brain disease

authors： Ryan JM,Tranah T,Mitry RR,Wendon JA,Shawcross DL

更新日期：2013-03-01 00:00:00

abstract：:Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjec...

journal_title：Metabolic brain disease

authors： Mustapic M,Popovic Hadzija M,Pavlovic M,Pavkovic P,Presecki P,Mrazovac D,Mimica N,Korolija M,Pivac N,Muck-Seler D

更新日期：2012-12-01 00:00:00

abstract：:Depression is a complex progressive disorder accompanied by activation of inflammatory and Th-1 driven pathways, oxidative and nitrosative stress (O&NS), lowered antioxidant levels, mitochondrial dysfunctions, neuroprogression and increased bacterial translocation. In depression, activation of immuno-inflammatory path...

journal_title：Metabolic brain disease

authors： Maes M

更新日期：2012-12-01 00:00:00

abstract：:There is abundant evidence showing that repeated use of MDMA (3, 4-Methylenedioxymethamphetamine, ecstasy) has been associated with depression, anxiety and deficits in learning and memory, suggesting detrimental effects on hippocampus. Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the...

journal_title：Metabolic brain disease

authors： Kermanian F,Mehdizadeh M,Soleimani M,Ebrahimzadeh Bideskan AR,Asadi-Shekaari M,Kheradmand H,Haghir H

更新日期：2012-12-01 00:00:00

abstract：:Niemann-Pick type C 1 (NPC1) disease is an autosomal recessive cholesterol transport defect resulting in a neurodegenerative process in patients mainly at an early age, although some patients may start with manifestation in adult. Since loss of myelin is considered as a main pathogenetic factor, the precise mechanism ...

journal_title：Metabolic brain disease

authors： Yan X,Lukas J,Witt M,Wree A,Hübner R,Frech M,Köhling R,Rolfs A,Luo J

更新日期：2011-12-01 00:00:00

abstract：:The present study analyses the potential role of MTHFR gene polymorphism, folate supplementation and dietary pattern among the mothers of NTD neonates and controls in heterogeneous populations of North India, with the special focus on their ethnic labels. Results indicated significant increased risk for neural tube de...

journal_title：Metabolic brain disease

authors： Deb R,Arora J,Meitei SY,Gupta S,Verma V,Saraswathy KN,Saran S,Kalla AK

更新日期：2011-09-01 00:00:00

abstract：:It has been suggested that antidepressants, including the selective serotonin reuptake inhibitors have neurotrophic effects. Nevertheless, the impact of treatment with a selective serotonin re-uptake inhibitor on regional brain volumes in social anxiety disorder has not been studied. 11 subjects with social anxiety di...

journal_title：Metabolic brain disease

authors： Cassimjee N,Fouche JP,Burnett M,Lochner C,Warwick J,Dupont P,Stein DJ,Cloete KJ,Carey PD

更新日期：2010-12-01 00:00:00

abstract：:We investigated the biochemical alterations of the striatum of mice subjected to seven experimental schedules with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) treatment. The mice were treated intraperitoneally (i.p.) with MPTP (20 mg/kg in saline) four times a day at 2-hr intervals showed severe ...

journal_title：Metabolic brain disease

authors： Kuroiwa H,Yokoyama H,Kimoto H,Kato H,Araki T

更新日期：2010-06-01 00:00:00

abstract：:Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 ye...

journal_title：Metabolic brain disease

authors： Norenberg MD

更新日期：2010-03-01 00:00:00

abstract：:There is evidence to suggest that, in acute liver failure (ALF), brain ammonia and proinflammatory cytokines may act synergistically to cause brain edema and its complications (intracranial hypertension, brain herniation). However, the molecular mechanisms involved remain to be established. In order to address this is...

journal_title：Metabolic brain disease

authors： Chastre A,Jiang W,Desjardins P,Butterworth RF

更新日期：2010-03-01 00:00:00

abstract：:Prenatal stress has been associated with increased vulnerability to psychiatric disturbances including schizophrenia, depression, attention-deficit hyperactivity disorder and autism. Elevated maternal circulating stress hormones alter development of neural circuits in the fetal brain and cause long-term changes in beh...

journal_title：Metabolic brain disease

authors： Mabandla MV,Kellaway LA,Daniels WM,Russell VA

更新日期：2009-12-01 00:00:00

abstract：:Cyclic AMP is part of an endogenous mechanism that downregulates inflammatory response, and its intracellular concentration is regulated chiefly by cyclic nucleotide phosphodiesterases type 4. The goal of the present study was to determine whether phosphodiesterases 4 are involved in the inflammatory response of astro...

journal_title：Metabolic brain disease

authors： Borysiewicz E,Fil D,Dlaboga D,O'Donnell JM,Konat GW

更新日期：2009-09-01 00:00:00

abstract：:gamma-Hydroxybutyric acid (GHB) is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased in the neurometabolic-inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity or due to intoxication. SSADH deficiency is biochemically characterize...

journal_title：Metabolic brain disease

authors： Sgaravatti AM,Magnusson AS,Oliveira AS,Mescka CP,Zanin F,Sgarbi MB,Pederzolli CD,Wyse AT,Wannmacher CM,Wajner M,Dutra-Filho CS

更新日期：2009-06-01 00:00:00

abstract：:In patients with hepatic encephalopathy (HE) the blood concentration of ammonia is usually highly elevated. Ammonia readily enters brain cells from the blood, and toxic effects of ammonia on brain metabolism and neurotransmission are believed to play a key role in the pathogenesis of HE. It has, however, been a matter...

journal_title：Metabolic brain disease

authors： Sørensen M,Munk OL,Keiding S

更新日期：2009-03-01 00:00:00

abstract：:Hepatic encephalopathy can be a life-threatening complication of fulminant hepatic failure. By understanding the pathophysiology involved in the induction of this neuropsychiatric disorder, future therapeutic and/or preventive attempts could be considered. In this study, an attempt has been made in order to shed more ...

journal_title：Metabolic brain disease

authors： Zarros A,Theocharis S,Skandali N,Tsakiris S

更新日期：2008-09-01 00:00:00

abstract：:Cystinosis is a systemic genetic disease caused by a lysosomal transport deficiency accumulating cystine in most tissues. Tissue damage depends on cystine accumulation, but the mechanisms of this damage are still obscure. Cysteamine administration depletes cystine accumulated, increasing survive of affected patients. ...

journal_title：Metabolic brain disease

authors： Kessler A,Biasibetti M,Feksa LR,Rech VC,Melo DA,Wajner M,Dutra-Filho CS,Wyse AT,Wannmacher CM

更新日期：2008-03-01 00:00:00

abstract：:Sepsis is a major clinical challenge that is associated with encephalopathy and multi-organ dysfunction. Current therapeutic interventions are relatively ineffective and the development of novel treatments is hampered by the lack of a well-characterised animal model. Therefore, the behavioural, metabolic, physiologica...

journal_title：Metabolic brain disease

authors： Brooks HF,Osabutey CK,Moss RF,Andrews PL,Davies DC

更新日期：2007-12-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) or branched-chain alpha-keto aciduria (BCKA) is an inherited disorder caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase complex (BCKAD) activity. The blockage of this pathway leads to tissue accumulation of the branched-chain amino acids (BCAA) leucine, isoleuc...

journal_title：Metabolic brain disease

authors： Barschak AG,Sitta A,Deon M,de Oliveira MH,Haeser A,Dutra-Filho CS,Wajner M,Vargas CR

更新日期：2006-12-01 00:00:00

abstract：:Increasing evidence indicates that fetal metabolic stress may result in a variety of post-natal perturbations during brain development. The goal of the study was to determine the duration of hypoxia/ischemia that would elicit a demonstrable regional depression of metabolism in the fetal brain and further to examine se...

journal_title：Metabolic brain disease

authors： Pundik S,Robinson S,Lust WD,Zechel J,Buczek M,Selman WR

更新日期：2006-12-01 00:00:00

abstract：:A study evaluating zinc supplementation in patients with Alzheimer's disease yielded variable zinc plasma levels in spite of positive cognitive and physiological results. In an attempt to raise and sustain plasma zinc levels, a single patient was given 15 mg zinc/day with various combinations of vitamins. A sustained ...

journal_title：Metabolic brain disease

authors： Potocnik FC,van Rensburg SJ,Hon D,Emsley RA,Moodie IM,Erasmus RT

更新日期：2006-09-01 00:00:00

abstract：:The sprouting of new blood vessels from pre-existing vasculature (angiogenesis) is essential for tumour survival, influenced by tumour cell-endothelial cell interactions and is tightly regulated by biochemical cues including the kallikrein-kinin system (KKS). We examined the structural interaction between neuroblastom...

journal_title：Metabolic brain disease

authors： Naidoo S,Raidoo DM

更新日期：2006-09-01 00:00:00